Only 20 percent of our longevity is genetically determined. The rest is what we do, how we live our lives and increasingly the molecules that we take. It's not the loss of our DNA that causes aging, it's the problems in reading the information, the epigenetic noise.
- David Andrew Sinclair
If you want to live a long life, focus on making contributions.
- Hans Selye
A light heart lives long.
- William Shakespeare
Personal health is related to self-control and to the worship of life in all its natural beauty - self-control bringing with it happiness, renewed youth, and long life.
- Maria Montessori
He had read much, if one considers his long life; but his contemplation was much more than his reading. He was wont to say that if he had read as much as other men he should have known no more than other men.
- Isaac Asimov
Tips for a long life - Keep Sweet, Keep Friendly, Keep Loving, if ye would ... keep Y O U N G
- Edgar Cayce
Deciding to commit yourself to long term results rather than short term fixes is as important as any decision you'll make in your lifetime.
- Anthony Robbins
Do not wait for life. Do not long for it. Be aware, always and at every moment, that the miracle is in the here and now.
- Marcel Proust
No man ever steps in the same river twice, for it's not the same river, and he's not the same man.
- Heraclitus
Most of the different types of cells in our body die and are replaced every few weeks or months. However, neurons, the primary cell of the nervous system, do not multiply (for the most part) after we are born. That means that the majority of the neurons in your brain today are as old as you are. This longevity of the neurons partially accounts for why we feel pretty much the same on the inside at the age of 10 as we do at age 30 or 77.
- Jill Bolte Taylor
Clinical Praxis™ Protocols
Longevity
Japan has the highest longevity of any nation. Within Japan, the highest longevity is found in Okinawa. Okinawa is a coral island, in contrast with volcanic geology of the rest of Japan. This results in highly alkaline water in Okinawa compared to the other prefectures...
Beyond higher longevity, alkaline drinking water is associated with
After this correlation was identified in Japan, similar studies in Europe confirmed the strong association of more alkaline drinking water with lower disease rates.
The blood must be maintained in a narrow range of alkalinity to maintain life. The reason fish die from acid rain is because the acidity binds oxygen causing the fish to asphyxiate.
When our cells become hypoxic (low oxygen), free radicals increase tissue damage and aging effects.
The body is made mostly of water. The quality of the water is a primary determinant of the biophysical terrain in the body. Disease states and pathogens can only thrive in certain limited ranges of terrain imbalance...
Healing water not only needs to supply alkaline minerals to balance acidity in the body. It also needs to supply electrons. Electrons combine with protons to form the perfect antioxidant, Molecular Hydrogen. While other antioxidants have the potential of blocking essential oxidative respiration in the mitochondria, there is no overdose risk with Molecular Hydrogen.
Technology developed in Japan in the 1960s produces water with these healing qualities. In fact, the units have been prescribed in Japan to the degree that about one in three households now benefit from this water technology.
Since the technology produces this healing water using electrolysis, the resulting water clusters are about half the size of those produced by other water filtration systems. This results in a much better solvent that also penetrates ten times better into the body tissues. This means better delivery of oxygen, nutrition, and phytonutrients, as well as better tissue and cell detoxification.
Natural Remedies for Longevity
Longevity research is showing us a range of specific nutrients and phytonutrients with benefits for quality of life and life extension. We combine a full spectrum of potent, optimum form botanical and nutritional ingredients in our Functional Formulation™ called Longevity. See the bottom of this page for full details, since we could not fit all of the information into the product listing in our store.
Animal research on a unique carbon compound known as Buckminster Fullerene recently found a dramatic increase in longevity with supplementation. Our Sanctuary C60 drops
There are two primary pathways of damage in the unhealthy aging process.
Anti-Oxidation
The chemical aging process with which you are probably most familiar is oxidation. In the catabolic process of oxidation, body tissues are 'burnt' or 'rusted' by unbalanced and untamed high energy substances known as free radicals. Many of those free radicals can come from the mitochondrial electron transport chain when there is insufficient oxygen available to receive the spent electrons at the end of the chain. That is an all-too-common tissue condition known as hypoxia. Free radicals seek to steal an electron wherever they can find one. If they take one from a lipid bilayer membrane, it tends to initiate a chain reaction, like a 'fire' in that oily layer. Our fundamental protections against this oxidative aging process are the components of the intracellular antioxidant system. These compounds, including Vitamin C, not only protect the cell against this damage, but they also support each other by regenerating the active forms of the compounds when they are spent in that protective process. That's why we developed a unique Functional Formulation that supplies the complete intracellular antioxidant network, called Synergy C. Synergy C is also synergistic with the alkaline, anti-oxidant, ionized water described above.
Anti-Glycation
A second major pathway of aging-related damage is glycation. Glycation is an anabolic reaction in which body tissues are damaged through covalent bonding with sugars. The sugars bind to proteins, oils, and nucleic acids, including both RNA and DNA. These damaged, dysfunctional compounds are referred to with the appropriate acronym AGE. AGE stands for Advanced Glycation Endproducts. Our Functional Formulation designed to protect against this aging damage, so the body's ongoing repair efforts can make progress at rejuvenation is called Reverse AGE. Reverse AGE is synergistic with Glucose Tolerance, which is designed to support restoration of healthy sugar regulation. Unfortunately, sugar dysregulation has become epidemic, ranging from Hypoglycemia to Metabolic Syndrome to Pre-Diabetes to Diabetes Types I and II...
Trauma
Trauma is another important contributor to aging. Macroscopic tissue damage results in scar formation. Scar tissue fails to restore the full function of the original tissue that was damaged. Scars also contract over time, constricting the flow of fluids, energy and information.
Scar tissue can be reduced and reformed closer to the original blueprint of the tissue with our natural therapies. Clear the Way, Vitality, and Rescue are core remedies for clearing scar tissue both visible and internal. See our Scar Reduction protocol to learn more...
Toxicity
Toxins build up in living tissues over time. They also build up more with elevation in the food chain. Half of the toxins that build up in human tissue over time are metabolites of the hormones and neurotransmitters of our stress responses. That means that when we improve our ability to manage stress, such as with EVOX Perception Reframing, we help ourselves tip the scales toward detoxification and longevity, on top of the massive benefits to quality of life.
Chelation and Binder Complex are core remedies for cleansing the vascular system and the gut. See our Chelation protocol to learn more...
Deficiency
The final facet of aging causality we must discuss is nutrient deficiency. In a sense, when contextually understood, deficiency is a unifying perspective for all of the types of causes of unhealthy aging and associated degeneration.
Every stressor, every toxin, and every trauma calls upon specific nutrients for resolution via adaptation, detoxification, and repair. When the resources needed exceed the available supply, a local or even systemic deficiency state is induced. Healing is limited, leaving scar tissue, toxic deposition, and impaired function all associated with a chronic stress state.
As the organism ages, these accumulations of incomplete healing processes deposit upon each other, layer upon layer, much like the layers that form a banded agate. Many healers describe the reverse aging process involved in the retracing and healing of these old wounds as peeling back the layers of an onion. This is a great metaphor for purposes of visualization. Perhaps thinking of the rings in a tree would be more technically apt, since the tree adds new rings on the outside...
Longevity is having a chronic disease - and taking care of it.
- Oliver Wendell Holmes, Jr.
Spirit Matters:
Body versus Mind
The soul is immortal, but which is more important for longevity in this life: the body or the mind? Both are important to both quality and quantity of life, obviously.
Exercise:
Results of 13 studies suggest that regular physical activity is associated with an increase of life expectancy by 0.4 to 6.9 years.
Source: ncbi.nlm.nih.gov › pmc › articles › PMC3395188
Nutrition:
The clarity of the eye's crystalline lens is one of the strongest predictors of longevity. It is avascular tissue like the joints, and it is the densest protein in the body, so it is physiologically furthest from its regional circulation. When tissue health is lost it is called a cataract, which can be removed surgically, but this fails to remove the underlying causes such as decreased circulation, and aging-related processes such as free radical pathology and glycation. This is why the average life expectancy following cataract surgery, the most common procedure in Medicare, is only 5 years. And it's why we consider our Cataract Solutions so important, whether or not surgery is needed or has already been performed. Just one example is Chromium, which is important to prevent Advanced Glycation Endproducts (AGE) formation, responsible for 1/3 of cataractogenesis. Chromium is the only essential mineral the kidneys are unable to conserve, and it is the first mineral lost to food processing and refining. Repletion of this one micro-mineral extends longevity by 5 years.
Happiness:
A meta-analysis based on 24 studies estimated that happy people live 14% longer than persons who report that they are unhappy. In a survey of people living in industrial countries, happier people enjoy an increased longevity of between 7.5 and 10 years.
Source: science.org/doi/10.1126/science.1201060
Over the course of studies averaging seven years long, research participants with larger social networks were about 45 percent less likely to die. In one study, elderly people who volunteered were 44 percent less likely to die over the course of a five-year study. In other studies, volunteers show lower levels of C-reactive protein and interleukin-6, both measures of inflammation. Research even suggests that those who engage in kind acts can see changes in the way genes for their immune system are expressed.
Source: greatergood.berkeley.edu/article/item/how_your_social_life_might_help_you_life_longer
Longevity is formulated to support your lifelong maintenance of optimum mitochondrial function.
Visualize supplying new spark plugs for your cells!
Longevity benefits include:
Supports optimum Nicotine Adenine Dinucleotide (NAD+) levels in the mitochondria
Promotes the delivery of high-energy electrons into the electron transport chain of oxidative cellular respiration that supplies cellular energy storage in the form of Adenosine Triphosphate (ATP)
Supports mitochondrial function
Mitochondrial dysfunction is the first observed precursor of glaucoma, many other neurodegenerative conditions, and chronic health problems generally.
NAD & Neurodegeneration Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC3422529/
NAD & Chronic Illness Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC4566449/
Restoring mitochondrial metabolism and stimulating mitochondrial biogenesis should be our first line of primary prevention against the effects of unhealthy aging and degeneration.
NAD and the related compound Nicotine Adenine Dinucleotide Phosphate (NADP) are the two most abundant coenzymes in healthy eukaryotic cells such as ours.
NAD is produced from Vitamin B3 in the mitochondria, and its depletion is a key marker of degeneration with aging-related diseases.
The Longevity formula is designed to optimize the high-energy electron source for the electron transport chain...
Lifestyle Synergists for Extending Lifespan:
In addition to taking Longevity 1 to 3 times a day with meals, you can promote your longevity potential several other ways:
Fasting: Avoid eating 3-4 hours before sleep, since hunger at bedtime increase NAD+.
Intermittent fasting 12-16 hours/day increases NAD levels via the enzyme Nicotinamide Phosphoribosyltransferase (NAMPT).
Calorie reduction or even water fasting for 4-5 days seasonally promotes autophagy and apoptosis.
Oleic acid activates SIRT 1 gene.
Real Olive or Avocado oil are beneficial, but we only recommend eating avocado and olives, as most commercial oils are adulterated or fake.
Aerobic exercise and resistance training are beneficial.
High-intensity interval training (HIIT) can be done 3x/week to achieve a 16% increase in the NAMPT enzyme that makes NAD.
Hydrotherapy is beneficial.
You can simply have a cold shower or use alternating heat and cold.
Learn more about Hydrotherapy at clinicalpraxis.com/hydrotherapy
Sauna or infrared therapies, especially NIR soft laser in the range of 810 to 820 nm are synergistic, affecting deep tissues.
For more details, see our Brain Helmet and our Harmony Laser.
Red Light Therapy in the range of 630 - 660 nm is synergistic, affecting superficial tissues, including all eye tissues.
For more details, see our Therapeutic Night Light, Red Light Therapy Flashlight, and Hair Growth Helmet.
Longevity References:
https://ncbi.nlm.nih.gov/pmc/articles/PMC4566449/
https://ncbi.nlm.nih.gov/pmc/articles/PMC5967606/
We found a few nutritional synergists that failed to qualify for inclusion in our formula:
Amines:
Tryptophan is a precursor for NAD production by forming niacin via the kyneurenine pathway, but it is not efficient enough to include because 60 mg of Tryptophan only makes 1 mg of niacin.
Leucine also increases NAD production, but also raises mTOR levels, the elevation of which is associated with reduced longevity, so adding Leucine would be counterproductive despite supporting increased NAD levels.
Also see the notes on why we don't include Niacinamide, below under Vitamins...
In fact, we don't even stock Niacinamide among the more than 500 ingredients we use in our hundreds of Functional Formulations™.
Longevity vegicaps are recommended 1 to 3 times a day with food or with meals.
Each vegicap of Longevity supplies:
Vitamins:
Vitamin B1: Thiamine (as Benfotiamine) 1.5 mg 100%
Thiamine recycles NAD.
Benfotiamine is a fat-soluble S-Acetyl precursor of Thiamine that crosses the Blood-Brain and Blood-Eye Barriers.
It is also useful for Alzheimer's, alcohol-related health issues, and nerve challenges in Diabetes.
Thiamine & Neuroprotection Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC5967606/
There's a series of brain scans showing long-term benefits of Benfotiamine in Alzheimer's patients below this collapsing section.
Vitamin B2: Riboflavin 5-Phosphate (R5P) 1.6 mg 100%
Riboflavin also recycles NAD.
R5P is the phosphorylated active coenzyme form of the vitamin.
Riboflavin Reference:
https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/
Vitamin B3:
Vitamin B3 (as Niacin) 8 mg 40%
We use low-dose niacin in our Bioavailability Factors (see below) to support increased blood flow and therefore tissue delivery of the other ingredients in each formula.
Larger doses, such as in our Blood Cleanse formulation, tend to cause a circulatory flush reaction for the first few days or weeks, so this should be considered with caution as an increased release of toxins from the perfused tissues can further burden organs of elimination such as the liver and kidneys.
Prolonged large doses of niacin, which we do not recommend, can increase insulin resistance.
Chromium, such as in Glucose Tolerance, can be supplied to help balance this effect.
Avoid time-release niacin in large doses as it can damage the liver.
Niacin's benefits include lowering LDL cholesterol, raising HDL cholesterol, lowering triglycerides & improving HDL/triglycerides balance.
Niacin decreases the incidence of cardiovascular, neurological, and aging-related issues.
Niacin Reference:
https://www.ncbi.nlm.nih.gov/books/NBK541036/
Vitamin B3 (as Niacinamide)
We do not include the Niacinamide form of Vitamin B3.
While it may form NR when taken with D-Ribose, large doses decrease SIRT1 activity over time in-vitro, and increase insulin resistance.
Vitamin B3 (as Nicotinamide Riboside) (NR) 50 mg *
We keep the dosage of NR low, since higher doses above about 125 mg may reduce performance.
Vitamin B3 (as Nicotinamide Mononucleotide) (NMN) 75 mg *
We also moderate the dosage of NMN, since some people may be concerned about abnormal DNA methylation.
NMN enhances performance and longevity.
It is being studied by David Sinclair at Harvard University to slow and reverse aging.
NMN and NR are two niacin-related precursors of NAD+ that are at the forefront of longevity research.
We maximize the beneficial effects and minimize any risks by combining safe doses of both.
Small doses of NADH can be used, but they are costly and very unstable, and unsuitable for encapsulation because they are highly hygroscopic.
Taken together in moderate doses, NMN and NR provide an efficient and well-tolerated means to increase NADH levels in the mitochondria.
Reference on NMN & NR:
https://pubmed.ncbi.nlm.nih.gov/29249689/
Vitamin B6: Pyridoxal 5-Phosphate (P5P) 2 mg 100%
Vitamin B6 recycles NAD.
P5P is the phosphorylated active coenzyme form of Pyridoxine.
Pyridoxine is associated with cardiovascular risk and lipids.
Vitamins & Longevity Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC2682456/
Vitamin B15: Trimethylglycine (TMG) 10 mg *
TMG (Betaine) is the best methyl donor that most efficiently repletes methyl groups depleted by all NAD boosters.
It is derived from beets, but to achieve a therapeutic dose, it must be extracted to avoid potential Iron toxicity.
People with high normal levels of Iron show reduced longevity compared to those with low normal levels.
Because TMG is hygroscopic, we can only include a small but significant dose in capsule formations as a catalyst.
For full therapeutic doses of TMG see our pleasant-tasting pure TMG powder.
Betaine Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC8224793/
Vitamin D3 (Cholecalciferol) 400 IU 10 mg 100%
Cholecalciferol raises NAD levels.
Vitamin D Reference:
https://pubmed.ncbi.nlm.nih.gov/26899162/
Quinones:
CoQ10 (Ubiquinone) 5 mg (from 25mg Ultra absorption formula) *
CoQ10 is synergistic with NAD+ in multiple clinical studies.
The combination helps restore mitochondrial function in Chronic Fatigue (CFS).
CoQ10 & NAD Reference:
https://pubmed.ncbi.nlm.nih.gov/26212172/
Lapachol 3% (Tabebuia avellanidae) 25 mg *
Lapachol increases the conversion of NADH to NAD+.
Pau D'Arco, the herbal source of Lapachol, is used as a cancer treatment in South American hospitals...
Like most chemotherapy agents, Lapachol also targets tumor cell glycolysis.
Pau D'Arco & Nrf2 Reference:
https://pubmed.ncbi.nlm.nih.gov/24646717/
Lapachol & Cancer Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC5796696/
Citric Acid Cycle Cofactors:
Pyruvate (Calcium Pyruvate) 10 mg *
Pyruvate, NAD & Senolytics Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC8552375/
Malate (Malic Acid) 15 mg *
Malate supports the conversion of NADH to NAD+.
Malate & Longevity Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC3589421/
C8 Fatty Acid:
R-Lipoate (Stabilized, Bioenhanced) 25 mg *
Lipoic Acid increases NAD levels.
Lipoic Acid Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC5961061/
Polyphenols:
Trans-Resveratrol (Polygonum cuspidatum) 25 mg *
Resveratrol, found in grapes, raises NAD levels in mitochondria, activates the SIRT 1 gene, and activates NAD.
Harvard longevity researcher David Sinclair compares NAD+ to fuel, and activators to a gas pedal.
Resveratrol Reference:
https://pubmed.ncbi.nlm.nih.gov/30741437/
Trans-Pterostilbene (Vaccinium cyanococcus) 25 mg *
Pterostilbene is methylated resveratrol.
This form found in blueberries is more potent and bioavailable than Resveratrol, and it activates the longevity-related SIRT 1 gene.
Pterostilbene & NR Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC5701244/
Apigenin (Matricaria chamomilla) 25 mg *
Chamomile increases NAD.
Apigenin inhibits the CD-38 enzyme that breaks down NAD.
Apigenin Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC3609577/
Rutin (Sophorae japonica) 25 mg *
Rutin inhibits the PARP1 enzyme related to gene repair that decreases NAD levels.
Rutin & NAD Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC6342515/
Quercetin DIhydrate (Sophora japonica) 25 mg *
Quercetin is the most common bioflavonoid in the diet and is the most researched of the polyphenols.
Quercetin activates NAD and inhibits CD38 and PARP1 enzymes that reduce NAD levels.
We use the water-soluble form: Quercetin Dihydrate because it is many times more bioavailable than the common form of Quercetin.
Quercetin & Apigenin Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC3609577/
Sumac Bran (Cotinus coggyria) 25 mg *
Sumac Bran is the highest ORAC food.
It is a source of the senolytic bioflavonoid Fisetin, which activates NAD.
Fisetin has neurotrophic, anticarcinogenic, and anti-inflammatory benefits.
Fisetin Reference:
https://ncbi.nlm.nih.gov/pmc/articles/PMC3689181/
Fisetin Neurological Reference:
https://pubmed.ncbi.nlm.nih.gov/34516952/
A Fibonacci sequence of 7 Bioavailability Factors is also included totaling 34 mg.
Bioavailability Factors:
Vitamin B13: Phosphatides 30% (Helianthus annuus) 21 mg *
EGb 761 (Ginkgo biloba) (24% Flavone Glycosides, 6% Lactones, <0.0005% Ginkgolic Acid) 13 mg *
Vitamin B3 (as Niacin) 8 mg 40%
Moringa 100:1 (Moringa oleifera) 5 mg *
Licorice Omnipotent (Glycyrrhiza glabra) 3 mg *
Gingerol 10% (Zingiber officinalis) 2 mg *
Piperine (Piper nigrum) 1 mg *
Vinpocetine (Vinca minor) 1 mg *
Visit FunctionalFormulations.com to learn more about our unique formulation process.
Visit ClinicalTheory.com to learn about our unique Clinical Theory of Everything™ upon which our entire system of Clinical Praxis™ is also based.
In ancient China, the Taoists taught that a constant inner smile, a smile to oneself, insured health, happiness and longevity. Why? Smiling to yourself is like basking in love: you become your own best friend. Living with an inner smile is to live in harmony with yourself.
- Mantak Chia